Introduction to Metrics in Person Centered Medicine Research

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Levent Kirisci
Michael Vanyukov
Juan E Mezzich


The articulation of science and humanism is at the core of Person Centered Medicine (PCM). Thus, applying the scientific method to advance our understanding of health and the improvement of health actions towards the fulfillment of the whole person is a permanent concern of PCM.

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Author Biography

Levent Kirisci, Professor of Pharmaceutical Sciences and Psychiatry, University of Pittsburgh; and Co-Investigator and Director of the Statistics Core of the U.S. NIDA-funded Center for Education and Drug Abuse Research.

I received an M.S. degree in applied statistics (1982) and M.A. and Ph.D. degrees (1985 and 1990) in mathematical and applied statistics, respectively.  Following a staff position at the University of Pittsburgh Medical School (1991-1994), I was appointed to the faculty in 1995 as Assistant Professor of Psychiatry in the University of Pittsburgh.  I was promoted to Associate Professor of Pharmaceutical Sciences and Psychiatry in 2003 and Professor in 2009.   I have been a recipient of Independent Scientist Award from U.S. National Institute on Drug Abuse (NIDA). I am also Co-Investigator and Director of the Statistics Core of the U.S. NIDA-funded Center for Education and Drug Abuse Research.  My primary expertise and research focus are devising and evaluating psychometric tools. I have been actively engaged in researching the applications of item response theory methodology and the properties of this methodology. I have spearheaded development of an interval scale to measure the psychological components of SUD liability common across the DSM-IV categories.  Employing item response theory, in conjunction with longitudinal multivariate modeling, a scale termed the liability index has been provisionally validated to quantify SUD risk at ages 10-12, 12-14, 16 and 19 in boys and girls.


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